College of Veterinary Medicine
Bachelor of Science (B.S.)
Citrated blood samples were collected via jugular venipuncture and used to create platelet-rich plasma (PRP). PRP samples were incubated for 5 minutes with four concentrations of glucosamine: 0 µ/ml (control), 10 µ/ml, and 100 µ/ml. Platelet aggregation was determined using turbidometric aggregometry using ADP or collagen as agonists. Thromboxane B2 concentrations were measured using a commercially available ELISA kit. The results were analyzed using mixed model analysis. Significance was set at p<0.05.
Rands, Gabrielle, "The in vitro effects of glucosamine on equine and canine platelet aggregation and thromboxane synthesis" (2017). Honors Theses. 4.