Theses and Dissertations

Issuing Body

Mississippi State University


Burgreen, Greg

Committee Member

Minerick, Adrienne

Committee Member

Reese, Donna

Committee Member

Lim, Hyeona

Date of Degree


Document Type

Graduate Thesis - Open Access


Computational Engineering (Program)

Degree Name

Master of Science


James Worth Bagley College of Engineering


Computational Engineering Program


To better understand how platelets behave when exposed to high shear stress, computational fluid dynamic (CFD) models for single-layer (uniform and constant) viscosity flow and two-layer (two distinct regions of different viscosities) viscosity flow were developed. The single-layer model, which represents common standard practice, did not predict the pressure drop correctly; the error produced from using the single-layer model was approximately 95%. However, the two-layer model produced results that were within 6% of the experimental results. Experimental results used to validate CFD models were obtained from data gathered by researchers at University Medical Center (UMC) in Jackson, MS. Using Fluent 6.2, simulations were performed that showed the characteristics of blood flow in a long stenosis. The beginning of the development of a blood damage model was also investigated. This thesis could provide researchers with information that will eventually allow the prediction of platelet activation and hemolysis.