Theses and Dissertations

Author

Sunghyun Yoon

Issuing Body

Mississippi State University

Advisor

Seo, Keun Seok

Committee Member

Pruett, Stephen B.

Committee Member

Woolums, Amelia

Committee Member

Brett, James A.

Date of Degree

8-9-2019

Original embargo terms

Worldwide

Document Type

Dissertation - Open Access

Major

Veterinary Medical Science

Degree Name

Doctor of Philosophy

College

College of Veterinary Medicine

Department

Veterinary Medical Science Program

Abstract

of S. aureus in bovine mastitis due to their potent toxicity toward host immune response. However, it has been a great challenge to determine the definite role of staphylococcal cytotoxins and SAgs in S. aureus pathogenesis due to the presence of multiple redundant cytotoxins and SAgs in a single S. aureus strain. Our long-term goal is to develop an effective vaccine to protect dairy cattle from S. aureus infection. The objective of this study is to; 1) determine the role of staphylococcal cytotoxins and superantigens in bovine mastitis; 2) develop a inducible and secretory expression vector and host system for a high production yield of recombinant protein; and 3) evaluate the protective effect of recombinant protein vaccine composed of staphylococcal cytotoxins and SAgs. The rationale of the proposed research is that development of an effective vaccine against S. aureus will prevent significant economic loss in the dairy industry and reduce the use of antibiotics in the dairy industry to prevent emergence of antibiotic resistance pathogens.

URI

https://hdl.handle.net/11668/14508

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