Author

Joe O Buntyn

Advisor

Rivera, J. Daniel

Committee Member

Schmidt, Ty B.

Committee Member

Carroll, Jeffrey A.

Committee Member

Smith, Trent

Date of Degree

1-1-2012

Document Type

Graduate Thesis - Open Access

Abstract

Nineteen heifers (274 ± 24 kg) were blocked into two treatment groups based upon DNAm; heifers with no DNAm (noQG), and heifers with one or more DNAm (1+QG). Prior to challenge (24 h), heifers were fitted with indwelling jugular catheters and indwelling vaginal temperature (VT) monitoring devices. Blood samples were collected at 30-min intervals while RT were collected at 1-min intervals from -2 to 8 h relative to a lipopolysaccride (LPS) challenge (0.5 ìg/kg BW) at 0 h. Serum was analyzed for concentrations of cortisol and pro-inflammatory cytokines. All physical, endocrine, and immune measurements increased relative to LPS challenge. No differences observed for IL-6 or TNF-á; however, 1+QG heifers had a greater circulating INF-ã (P < 0.001). Furthermore, 1+QG heifers had an elevated VT (P = 0.04). This would suggest a different immune system approach to an LPS challenge.

URI

https://hdl.handle.net/11668/19076

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