Theses and Dissertations


Joe O. Buntyn

Issuing Body

Mississippi State University


Rivera, J. Daniel

Committee Member

Schmidt, Ty B.

Committee Member

Carroll, Jeffrey A.

Committee Member

Smith, Trent

Date of Degree


Document Type

Graduate Thesis - Open Access


Nineteen heifers (274 ± 24 kg) were blocked into two treatment groups based upon DNAm; heifers with no DNAm (noQG), and heifers with one or more DNAm (1+QG). Prior to challenge (24 h), heifers were fitted with indwelling jugular catheters and indwelling vaginal temperature (VT) monitoring devices. Blood samples were collected at 30-min intervals while RT were collected at 1-min intervals from -2 to 8 h relative to a lipopolysaccride (LPS) challenge (0.5 ìg/kg BW) at 0 h. Serum was analyzed for concentrations of cortisol and pro-inflammatory cytokines. All physical, endocrine, and immune measurements increased relative to LPS challenge. No differences observed for IL-6 or TNF-á; however, 1+QG heifers had a greater circulating INF-ã (P < 0.001). Furthermore, 1+QG heifers had an elevated VT (P = 0.04). This would suggest a different immune system approach to an LPS challenge.