Title

Implant-Related Osteomyelitis Models for the Assessment of Bacteriophage Therapeutics

Advisor

Priddy, Lauren

Committee Member

Swanson, Elizabeth

Committee Member

Seo, Keun

Committee Member

Elder, Steve

Date of Degree

1-1-2019

Original embargo terms

Visible to MSU only for 1 Year

Document Type

Graduate Thesis - Open Access

College

James Worth Bagley College of Engineering

Department

Department of Agricultural and Biological Engineering

Abstract

Antibiotic resistant strains of bacteria continue to increase in prevalence, hindering the ability of clinicians to treat infection. One disease exacerbated by this trend is osteomyelitis, or bone infection. When osteomyelitis is induced by these antibiotic resistant strains, patients can experience prolonged hospital visits, greater economic burdens, amputation, and even death. Due to the limitations of antibiotics to clear these infections, we sought to identify new therapeutic options for osteomyelitis. Our aim was to first develop an in vivo implant-related model of osteomyelitis. We then wanted to explore the potential of novel CRISPR-Cas9 modified bacteriophage to treat infection. In vitro and in vivo investigations demonstrated that bacteriophage therapeutic may be a viable option for infection mitigation. Furthermore, our in vivo model of osteomyelitis proved to be reliable, consistent, and challenging. Future research will utilize this model as a platform for optimizing therapeutic regimen and delivery vehicle(s) for antimicrobial therapeutics.

URI

https://hdl.handle.net/11668/21221

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