Innate and adaptive immune responses of channel catfish to Edwardsiella ictaluri wild type and live attenuated vaccine candidates
Lawrence, Mark L.
Hanson, Larry A.
Date of Degree
Original embargo terms
Complete embargo for 2 years||2 Years||8/15/2022
Graduate Thesis - Open Access
Master of Science
College of Veterinary Medicine
Department of Basic Sciences
Edwardsiella ictaluri causes enteric septicemia of catfish (ESC), a devastating disease in the channel catfish industry. Our research group has developed several E. ictaluri live attenuated vaccine (LAV) candidates (EiΔevpB, EiΔevpBΔfur, EiΔevpBΔhfq, EiΔevpBΔfurΔhfq), which were able to stimulate an immune response in vaccinated channel catfish and reduce ESC. However, innate, and adaptive immune responses in the lymphoid tissues of channel catfish to these LAVs are not known well. The overall goal of the project is to determine the role of adaptive and innate immune responses in catfish after vaccination with LAVs. Analysis of innate and adaptive immune-related gene expressions showed that the LAVs induced expression of adaptive immune-related genes in lymphoid tissues with less inflammation compared to wild type control. Also, the LAVs induced the expression of IgM in the sera of catfish.
Erdogan, Ozgur, "Innate and adaptive immune responses of channel catfish to Edwardsiella ictaluri wild type and live attenuated vaccine candidates" (2020). Theses and Dissertations MSU. 2740.