Title

Innate and adaptive immune responses of channel catfish to Edwardsiella ictaluri wild type and live attenuated vaccine candidates

Author

Ozgur Erdogan

Advisor

Lawrence, Mark L.

Committee Member

Karsi, Attila

Committee Member

Pinchuk, Lesya

Committee Member

Hanson, Larry A.

Date of Degree

8-1-2020

Original embargo terms

Complete embargo for 2 years||2 Years||8/15/2022

Document Type

Graduate Thesis - Open Access

Degree Name

Master of Science

College

College of Veterinary Medicine

Department

Department of Basic Sciences

Abstract

Edwardsiella ictaluri causes enteric septicemia of catfish (ESC), a devastating disease in the channel catfish industry. Our research group has developed several E. ictaluri live attenuated vaccine (LAV) candidates (EiΔevpB, EiΔevpBΔfur, EiΔevpBΔhfq, EiΔevpBΔfurΔhfq), which were able to stimulate an immune response in vaccinated channel catfish and reduce ESC. However, innate, and adaptive immune responses in the lymphoid tissues of channel catfish to these LAVs are not known well. The overall goal of the project is to determine the role of adaptive and innate immune responses in catfish after vaccination with LAVs. Analysis of innate and adaptive immune-related gene expressions showed that the LAVs induced expression of adaptive immune-related genes in lymphoid tissues with less inflammation compared to wild type control. Also, the LAVs induced the expression of IgM in the sera of catfish.

URI

https://hdl.handle.net/11668/18008

Comments

Edwardsiella ictaluri||channel catfish||adaptive immune responses||pro-inflammatory cytokines||live attenuated vaccines||Enteric septicemia of catfish||antibody titer

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