Theses and Dissertations

Issuing Body

Mississippi State University


Williams, Lakiesha N.

Committee Member

Olivier, Alicia Kathleen

Committee Member

Liao, Jun

Committee Member

Jones, Michael D.

Committee Member

Prabhu, Rajkumar Prabhu

Date of Degree


Document Type

Graduate Thesis - Open Access


Biomedical Engineering

Degree Name

Master of Science


James Worth Bagley College of Engineering


Department of Agricultural and Biological Engineering


Traumatic brain injury (TBI) is a growing concern among American citizens and globally. This study proposes the use of a novel mechanical testing method for interrupting adult porcine brain tissue while under varying levels of high rate compressive strain to better understand the mechanical response of brain while under TBI inducing conditions. Testing was performed using a polymeric Split Hopkinson Pressure Bar (SHPB) along with customized attachments developed in-house to interrupt tissue samples at strain levels of 15%, 30%, and 40% while being compressed at strain rates of 650, 800, and 900 s-1. Following interruption, the samples were chemically fixed in preparation for histological processing. Microscopy techniques were used to examine the microstructure of the deformed tissue samples and measure the area fraction of their neural constituents. The combination of both the mechanical and microstructural responses of the brain tissue allowed for the development of a structure-property relationship.



biomechanics||TBI||porcine||brain||split Hopkinson pressure bar||high-rate||interruption