Theses and Dissertations

Issuing Body

Mississippi State University


Warnock, James

Committee Member

Horton, Renita

Committee Member

Janus, Mark

Date of Degree


Document Type

Graduate Thesis - Open Access


Biomedical Engineering

Degree Name

Master of Science


James Worth Bagley College of Engineering


Department of Agricultural and Biological Engineering


A left ventricular assist device is a mechanical pump implanted in patients with heart failure that continuously takes blood from the left ventricle and delivers it to the aorta, thus decreasing ventricular load. The device is typically considered as a ‘bridge to transplant’, i.e. as a temporary therapy, and involves several risks. Modified ventricular hemodynamics due to a heart pump implantation is studied in-vitro using an elastic ventricle. The ventricle is incorporated into a pulse duplicator setup, which prescribes realistic pulsatile inflow/outflow to mimic a weak ejection fraction. A continuous axial pump mimics a ventricular assist device and its effect on the ventricular hemodynamics is investigated as a function of the pump flow suction. Using particle image velocimetry, pump flow effectiveness at providing unloading on the ventricle and increasing ejection is observed and understanding if proper recirculation of the myocardium down to the apex is restored under varying flow rate.



Cardiomyopathy||ejection fraction||fluid dynamics||left ventricle||ventricular assist device||particle image velocimetry