Mississippi State University
Date of Degree
Graduate Thesis - Open Access
Master of Science
James Worth Bagley College of Engineering
Department of Agricultural and Biological Engineering
A left ventricular assist device is a mechanical pump implanted in patients with heart failure that continuously takes blood from the left ventricle and delivers it to the aorta, thus decreasing ventricular load. The device is typically considered as a ‘bridge to transplant’, i.e. as a temporary therapy, and involves several risks. Modified ventricular hemodynamics due to a heart pump implantation is studied in-vitro using an elastic ventricle. The ventricle is incorporated into a pulse duplicator setup, which prescribes realistic pulsatile inflow/outflow to mimic a weak ejection fraction. A continuous axial pump mimics a ventricular assist device and its effect on the ventricular hemodynamics is investigated as a function of the pump flow suction. Using particle image velocimetry, pump flow effectiveness at providing unloading on the ventricle and increasing ejection is observed and understanding if proper recirculation of the myocardium down to the apex is restored under varying flow rate.
Jermyn, Elizabeth, "Left Ventricular Hemodynamics with Reduced Ejection Fraction: An In-Vitro Piv Study using an Implanted Assisting Device" (2018). Theses and Dissertations. 2938.