Wan, Xiufeng (Henry)
Other Advisors or Committee Members
Pharr, G. Todd||Hanson, Larry||Hoblet, Kent H.
Date of Degree
Original embargo terms
Graduate Thesis - Open Access
Veterinary Medical Science
Master of Science
College of Veterinary Medicine
Department of Basic Sciences
Sialic acids (Sias) are receptors for influenza A viruses (IAVs). The influence of individual sialyltransferases on the Sias expressed is not understood. Also, sensitive methods to distinguish Sias on the cells are lacking. Our goals were to establish a method to detect Sias on the cell and to evaluate the importance of CMP-sialic acid transporter (SLC35A1) and ST6 beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) for IAV infection. Aproximity ligation assay was established to detect and quantify Sias.
Jiang, Kaijun, "Novel methods for detecting glycan receptors for influenza A virus and exploration of the function of the sialyltransferases on influenza viral infection" (2019). Theses and Dissertations MSU. 3315.