Author

Kaijun Jiang

Advisor

Wan, Xiufeng (Henry)

Other Advisors or Committee Members

Pharr, G. Todd||Hanson, Larry||Hoblet, Kent H.

Date of Degree

8-1-2019

Original embargo terms

7/19/2020||

Document Type

Graduate Thesis - Open Access

Major

Veterinary Medical Science

Degree Name

Master of Science

College

College of Veterinary Medicine

Department

Department of Basic Sciences

Abstract

Sialic acids (Sias) are receptors for influenza A viruses (IAVs). The influence of individual sialyltransferases on the Sias expressed is not understood. Also, sensitive methods to distinguish Sias on the cells are lacking. Our goals were to establish a method to detect Sias on the cell and to evaluate the importance of CMP-sialic acid transporter (SLC35A1) and ST6 beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) for IAV infection. Aproximity ligation assay was established to detect and quantify Sias.

URI

https://hdl.handle.net/11668/14591

Comments

Influenza virus||silica acid receptor||CRISPR||PLA

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