Burgess, C. Shane
Date of Degree
Graduate Thesis - Open Access
Veterinary Medical Science
Master of Science
College of Veterinary Medicine
Department of Clinical Sciences
Hereditary equine regional dermal asthenia (HERDA) is a recessive connective tissue disorder of Quarter Horse lineages. This study correlates previously identified decreases in skin tensile strength in HERDA with abnormal dermal collagen cross linking patterns that are also identified in urine from HERDA horses. Dermal collagen from HERDA horses has significantly less pyridinoline and significantly more deoxypyridinoline than control or carriers. Concentrations of hydroxylysine, the rate limiting substrate for these crosslinks were significantly lower in HERDA versus control and carriers. These characteristics of HERDA skin parallel humans with a similar syndrome of skin fragility, Ehlers Danlos Syndrome TypeVIA. This is the first biochemical evidence explaining the clinical skin fragility that characterizes HERDA and suggests that altered collagen lysine metabolism may be physiologically relevant to the clinical manifestation of HERDA. Evaluations of mature scars indicate that lesion and nonlesioned skin should not be viewed as biologically equivalent in HERDA investigations.
Hill, Ashley Arwen, "Skin from horses with hereditary equine regional dermal asthenia (HERDA) contains collagen crosslinking patterns that are associated with reduced tensile strength" (2010). Theses and Dissertations MSU. 3962.