Advisor

Walters, Keisha B.

Committee Member

Elmore, Bill B.

Committee Member

Hill, Priscilla J.

Date of Degree

1-1-2012

Document Type

Graduate Thesis - Open Access

Degree Name

Master of Science

College

James Worth Bagley College of Engineering

Department

Dave C. Swalm School of Chemical Engineering

Abstract

Interactions of Asthma Drugs with Artificial Saliva and Mucus. Modeling pulmonary particulate transport requires related biofluid physicochemical properties. Aims included measuring the effects of common aerosol drugs on artificial saliva and diffusivities of asthma medications in mucus. Artificial saliva solutions doped with asthma medications were characterized by pH, interfacial tension, and rheology. To measure diffusion, drug concentration was monitored by time-dependent FTIR spectra, and diffusivity obtained using Fick¡¦s second law. Measured theophylline and albuterol diffusivities were ca. 10-6 cm2/s. Surface Modification of Polymer Films with Light-Emitting Chemicals. To develop a polymer film system that changed color in response to radiation, acid groups of poly(ethylene-co-acrylic acid) were used to attach two light-emitting polymers: 4„S-(octyloxy)-4-biphenylcarboxylic acid and 2,7-bis(bromomethyl)-9,9-dihexyl-9Hluorene. Each reaction step was confirmed using static contact angle goniometry, FTIR spectroscopy, and X-ray photoelectron spectroscopy. UV-Vis and fluorescence spectroscopy measured the absorption spectra. Modified films were irradiated (ƒÜ=254 nm) and produced blue emissions.

URI

https://hdl.handle.net/11668/18310

Comments

film||light emission||polymer||saliva||albuterol||theophylline||mucus||diffusion||diffusion coefficient||polyethylene||radiation

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