Theses and Dissertations

Issuing Body

Mississippi State University


Mackin, Andrew

Committee Member

Langston, Cory

Committee Member

Pinchuk, Lesya

Committee Member

Linford, Robert

Committee Member

Pruett, Stephen

Date of Degree


Document Type

Graduate Thesis - Open Access


Veterinary Medical Science

Degree Name

Master of Science


College of Veterinary Medicine


Immune-mediated hemolytic anemia (IMHA) is one of the most common causes of anemia in dogs. Despite aggressive therapy, there is a 50% mortality rate in IMHA patients, and the most common cause of death is thromboembolic disease, particularly pulmonary thromboembolism. With the high thromboembolism rate in dogs with IMHA, anti-platelet therapy with aspirin can be a life-saving preventative therapy. Along with anti-platelet therapy, immunosuppressive therapy is needed to decrease erythrocyte destruction. Cyclosporine has become a popular medication for immunosuppression in IMHA patients. Unfortunately, recent human reports have suggested that cyclosporine could activate platelets and contribute to a hypercoagulable state. With the goal of improving therapy, these studies investigated the role aspirin plays in inhibiting platelet function and cyclooxygenase expression, an enzyme that enhances platelet reactivity. The effect of cyclosporine on platelet reactivity and hypercoagulablity was investigated to determine if this medication would create activated platelets and a prothrombotic state.