Advisor

Buddington, Randal K.

Committee Member

Braasch, Dwaine A.

Committee Member

Pulakat, Lakshmidevi

Date of Degree

1-1-2007

Document Type

Graduate Thesis - Open Access

Degree Name

Master of Science

College

College of Arts and Sciences

Abstract

The resident microbes of human gastrointestinal tract cause both harmful and beneficial effects and these effects can be modulated by the administration of beneficial probiotic bacteria. Probiotics attribute several therapeutic and preventive beneficial effects, for both humans and animals. Despite the good effects of probiotic bacteria, the role of probiotic bacteria or their metabolites on the nutrient uptake by enterocytes is very less known. Most studies describe the genomic effects of probiotic bacteria on the transport properties. This thesis describes the short term (10 min or less) non-genomic effects of probiotic bacteria on the glucose uptake by human enterocytes like Caco-2 cells. The focus of the present study was to identify if metabolites of Lactobacilli sp. trigger a rapid non genomic regulation of glucose transporter proteins of enterocytes. The findings indicate that the regulatory molecules of bacterial metabolites can cause a rapid increase in glucose uptake by enterocytes.

URI

https://hdl.handle.net/11668/17835

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