Theses and Dissertations

Issuing Body

Mississippi State University


Lindsey, Merry L.

Committee Member

Elder, Steven H.

Committee Member

Simpson, C. LaShan

Committee Member

Stewart Jr., James A.

Committee Member

Cathcart, Thomas P.

Date of Degree


Document Type

Graduate Thesis - Open Access

Degree Name

Master of Science


James Worth Bagley College of Engineering


Otolin-1 is a collagenous, C1q domain-containing extracellular matrix protein that has been identified and characterized in the inner ear. Recently, mass spectrometry analysis of left ventricular cardiac tissue detected a peptide of Otolin-1. Experimental analysis confirms Otolin-1 is an insoluble protein present in the left ventricular extracellular matrix whose expression decreases dramatically post-myocardial infarction beginning at day 5 post-MI. The protein is localized to the gap junctions of cardiac myocytes, and depletion of protein levels in the infarcted region of the left ventricle shows strong association with ventricular dimensions, observed via echocardiography.