Advisor

Dodson, L. Wanda

Committee Member

Rude, J. Brian

Committee Member

Wilson, P. Robert

Committee Member

Mixon, Melissa

Committee Member

Ryan, L. Peter

Date of Degree

1-1-2008

Document Type

Dissertation - Open Access

Degree Name

Doctor of Philosophy

Abstract

Recent reports suggest that preeclampsia is the result of an excessive maternal systemic inflammatory response. The role of magnesium and systemic inflammation in normal pregnancy and preeclampsia needs to be defined. The objectives of this study were to compare (1) demographic and (2) anthropometric characteristics of normal and preeclamptic pregnant women; and (3) to determine and compare serum iMg++ and tMg concentration and the association between inflammatory makers such as TNFα, leptin, adiponectin, IL10, ET-1, triacylglycerol, FFA, serum iMg++ and, tMg concentration of normal and preeclamptic pregnant women during the third trimester of pregnancy. Thirtyfive healthy pregnant and thirtyive preeclamptic pregnant women in their third trimester volunteered to participate in the study. Analyses were done by the use of ion-selective electrode, atomic absorption spectrometry, spectrophotometry, and ELISA kits. Pregnant normal and preeclamptic subjects were paired by age, parity, and week of gestation. Gestational age, body weight, age, prepregnancy diastolic BP, intake of birth control pills, supplements, miscarriage, still births, race, and employment status were statistically unchanged between the two groups. Current systolic and diastolic BP, family history of preeclampsia, urine albumin, minimum, maximum temperature and precipitation at the time of presentation were found to be significantly increased in the preeclamptic group. Number of children and pregnancies were significantly higher in the normal pregnant group. In the preeclampsia group, TNFα, ET-1, leptin, FFA, and triacylglycerol blood concentrations increased while tMg, IL10, and adiponectin blood concentrations decreased. Significant positive correlation was recorded between iMg++ and tMg and between iMg++ and tMg with IL10 and adiponectin in the preeclamptic group. An inverse correlation of iMg++ and tMg with TNFα, ET-1, leptin, FFA, and triacylglycerol, was seen in the preeclamptic group. Understanding the role of demographics and anthropometric characteristic during pregnancy and preeclampsia along with high correlation of iMg++ and tMg with each other and with inflammatory markers, increase in blood concentration of TNFα, ET-1, leptin, FFA, and triacylglycerol, and decrease in blood concentration of tMg, IL 10, and adiponectin could be an important step in understanding the pathophysiology of preeclampsia.

URI

https://hdl.handle.net/11668/15540

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