Theses and Dissertations

Issuing Body

Mississippi State University

Advisor

Karisch, Brandi B.

Committee Member

Vann, Rhonda C.

Committee Member

Woolums, Amelia

Date of Degree

12-10-2021

Document Type

Graduate Thesis - Open Access

Major

Agriculture

Degree Name

Master of Science (M.S.)

College

College of Agriculture and Life Sciences

Department

Department of Animal and Dairy Sciences

Abstract

Bovine respiratory disease (BRD) is the leading cause of morbidity and mortality in beef cattle. Common management practices in addition to BRD have been shown previously to cause inflammation. The objectives of this study were: (1) characterize the inflammatory profiles as indicated by interleukin-1 beta (IL-1β) and haptoglobin concentrations; (2) evaluate the impact of on-arrival metaphylactic antimicrobial therapy on inflammatory profiles in high risk cattle; and (3) examine the relationship between inflammatory profile and BRD morbidity and mortality. Eighty sale barn heifers were purchased over a two-year period (n=160). At arrival, heifers were randomly assigned to either receive tulathromycin (Draxxin, META, n=40) or not (NO META, n=40). Inflammatory profiles remained increased for all groups through d70 (P = 0.028). Metaphylaxis did not affect haptoglobin concentration (P > 0.10). There was a significant increase in BRD cases from day 0 to 20 (P = 0.002). Morbidity (BRD vs no BRD) did not impact haptoglobin concentrations.

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