Bumgardner, Joel D.
Date of Degree
Graduate Thesis - Open Access
Master of Science
The material characteristics play a role in the suitability of chitosan for biomedical applications. This is not surprising since the degree of deacetylation of chitosan influences antimicrobial activity, degradation rate, immune reaction and mechanical properties such as strength and elongation. This study examines chitosans of variable material characteristics for wound and bone healing applications. Chitosan films of 76, 78, 80, 87, 91, 92, and 95% degree of deacetylation were tested in vitro for cellular responses by fibroblast and bone cell lines. The in vitro responses were compared to the material characteristics of molecular weight, degree of deacetylation, swelling index, and ash content.
Hamilton, Virginia, "An In Vitro Evaluation Of Chitosan As A Biomaterial Focusing On The Effects Of The Degree Of Deacetylation" (2004). Theses and Dissertations MSU. 562.