An In Vitro Evaluation Of Chitosan As A Biomaterial Focusing On The Effects Of The Degree Of Deacetylation

Author

Virginia Hamilton

Issuing Body

Mississippi State University

Advisor

Bumgardner, Joel D.

Committee Member

Puckett, Aaron

Committee Member

Ryan, Jack

Committee Member

Cooper, Robert

Committee Member

Elder, Steve

Date of Degree

12-11-2004

Document Type

Graduate Thesis - Open Access

Major

Biomedical Engineering

Degree Name

Master of Science

College

James Worth Bagley College of Engineering

Department

Department of Agricultural and Biological Engineering

Abstract

The material characteristics play a role in the suitability of chitosan for biomedical applications. This is not surprising since the degree of deacetylation of chitosan influences antimicrobial activity, degradation rate, immune reaction and mechanical properties such as strength and elongation. This study examines chitosans of variable material characteristics for wound and bone healing applications. Chitosan films of 76, 78, 80, 87, 91, 92, and 95% degree of deacetylation were tested in vitro for cellular responses by fibroblast and bone cell lines. The in vitro responses were compared to the material characteristics of molecular weight, degree of deacetylation, swelling index, and ash content.

URI

https://hdl.handle.net/11668/17272

Recommended Citation

Hamilton, Virginia, "An In Vitro Evaluation Of Chitosan As A Biomaterial Focusing On The Effects Of The Degree Of Deacetylation" (2004). Theses and Dissertations. 562.
https://scholarsjunction.msstate.edu/td/562