Theses and Dissertations

Advisor

Seitz, Marc A.

Committee Member

Lee, Alison M.

Committee Member

Fizzano, Kristen M.

Committee Member

Mackin, Andrew

Date of Degree

5-16-2025

Original embargo terms

Immediate Worldwide Access

Document Type

Graduate Thesis - Open Access

Major

Veterinary and Biomedical Science (Veterinary Medical Research)

Degree Name

Master of Science (M.S.)

College

College of Veterinary Medicine

Department

Department of Clinical Sciences

Abstract

Ultrasonography can be used in dogs to visualize urine entering the urinary bladder (ureteral jets) to determine whether urine enters the bladder normally. Dexmedetomidine is an alpha-2 adrenergic agonist used for chemical restraint and has diuretic properties. The purpose of this study is to evaluate the effect of dexmedetomidine on the number of jets detected using B-mode ultrasonography. We hypothesized: that intravenous administration of dexmedetomidine would cause increased numbers of jets; that jets would increase with increasing doses of dexmedetomidine and length of sedation. Compared to baseline, increases in observed jets occurred at 30- and 40-minutes post 3 mcg/kg (p=0.042 and p=0.023). Compared to 10-minutes post sedation, increases in the number of jets occurred at 20-, 30-, and 40-minutes (p=0.0032, p< 0.0001, and p< 0.0001). This was not observed at 5 mcg/kg. Findings suggest administering 3 mcg/kg dexmedetomidine intravenously could cause increased jet numbers on B-mode ultrasound after 30-40 minutes.

Sponsorship (Optional)

American College of Veterinary Radiology

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