Theses and Dissertations

ORCID

https://orcid.org/0009-0008-6728-2272

Advisor

Priddy, Matthew W.

Committee Member

Priddy, Lauren B.

Committee Member

Dickel, Doyl E.

Committee Member

Moore, Jacob L.

Date of Degree

5-16-2025

Original embargo terms

Visible MSU Only 1 year

Document Type

Dissertation - Campus Access Only

Major

Engineering (Mechanical Engineering)

Degree Name

Doctor of Philosophy (Ph.D.)

College

James Worth Bagley College of Engineering

Department

Michael W. Hall School of Mechanical Engineering

Abstract

While magnesium and its alloys are viable biodegradable implant candidates for its similarity of Young’s modulus with human bone and its strong biocompatibility, a pure magnesium scaffold degrades too rapidly to be used in many orthopedic implications. Overcoming this high degradation rate has been one of the biggest technical challenges for Mg-based biomedical applications. This research focuses on validating a finite element analysis framework using a continuum damage model and its application to simulate the degradation process of non-coated additively manufactured WE43 and HA-coated WE43 magnesium scaffolds. This work includes determining model input parameters by matching in vitro experiment results and investigating the details of HA coating effects for biodegradable magnesium scaffolds. This research extends the models by applying long-time degradation for HA-coated WE43 magnesium scaffolds to determine the long-term mechanical integrity of such biodegradable implants. Furthermore, it examines the effect of the HA coating thickness, which serves as a benchmark for surface-modified coated biodegradable implant models for determining the optimal thickness of the HA coating. This research is significant because it is: 1) A predictive finite element degradation model for HA-coated WE43 magnesium scaffold calibrated using in vitro experiment. Micrometer-level fine mesh size HA coating finite element simulation gives us insight into the effect of HA coating on suspending degradation when applied to biomedical areas. 2) Expanding the degradation models by applying long-time degradation for HA-coated WE43 magnesium scaffold gives us the knowledge for long-time degradation up to 250 days close to practical implications in biodegradable implants. 3) A comprehensive comparison of the proposed HA-coated WE43 magnesium scaffold finite models using a continuum damage model with in vitro degradation experiments. 4) The implementation of the proposed HA-coated WE43 scaffold framework to examine the degradation of HA-coated scaffold in vitro experiment with the capacity of multi-layered micro level of details to investigate of HA coating thickness effect, which serves standard for surface-modified coated biodegradable implant models by providing HA coating thickness effect for optimal treatment of HA coating for the magnesium scaffold.

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