
Theses and Dissertations
ORCID
https://orcid.org/0009-0009-7204-9835
Advisor
Emerson, Joseph P.
Committee Member
Stokes, Sean L.
Committee Member
Collins, Galen A.
Date of Degree
5-16-2025
Original embargo terms
Immediate Worldwide Access
Document Type
Graduate Thesis - Open Access
Major
Chemistry
Degree Name
Master of Science (M.S.)
College
College of Arts and Sciences
Department
Department of Chemistry
Abstract
This thesis explores two sustainable methodologies by modifying established catalytic processes using group ten metal complexes from nickel and palladium. Efforts were made to provide alternatives for processes that often do not follow the principles of green chemistry. In the first project, a nickel(II) N-heterocyclic carbene complex was used to perform catalytic hydrogenation of 2-acetylpyridine under mild conditions. The complex was synthesized and characterized with techniques including mass spectrometry and 1H-NMR. Following this, the reactions were carried out to optimize conditions and yield moderate conversions. For the second project, the Suzuki-Miyaura cross coupling of 7-chlorotryptophan occurred utilizing a palladium complex with the Buchwald ligand sSPhos. The research investigated challenges with aryl chlorides and performed optimizations for successful coupling. Products with a significant variation to the fluorescent emission were identified utilizing LC-MS and were discussed with other byproducts. The resulting yields were estimated to show moderate conversion with minimal signal overlap.
Recommended Citation
Perkins, Amanda M., "Enhancing chemical synthesis for sustainability and process monitoring utilizing group ten metal catalysis" (2025). Theses and Dissertations. 6553.
https://scholarsjunction.msstate.edu/td/6553