Theses and Dissertations

Issuing Body

Mississippi State University


Mackin, Andrew

Committee Member

Claude, Andrew

Date of Degree


Document Type

Graduate Thesis - Open Access

Degree Name

Master of Science


Respiratory disease represents an important component of small animal emergency medicine. The morbidity and mortality of respiratory disease and inflammation, although poorly defined, is considered to be significant. Much of the therapy used in the stabilization and management of respiratory disease in veterinary patients has been taken from human medicine, including inhalation therapy. Heparin has been shown to have substantial anticoagulant, anti-inflammatory, and antiibrotic effects within the lungs when administered via inhalation in human patients. To date, no studies have evaluated the use of nebulized heparin in dogs. This study is the first to attempt to generate pharmacokinetic data regarding nebulized unfractionated heparin in the dog.