Author

Julianna Frum

Advisor

Thomason, John M.

Committee Member

Mackin, Andrew J.

Committee Member

Eubanks, Diana L.

Committee Member

Archer, Todd M.

Committee Member

Langston, V. Cory

Date of Degree

5-1-2020

Original embargo terms

Visible to MSU only for 6 months||forever||10000-01-01

Document Type

Graduate Thesis - Open Access

Degree Name

Master of Science

Abstract

Enoxaparin, a low-molecular-weight heparin, is commonly used as an anticoagulant in dogs, and is currently dosed at 0.8mg/kg every 6 hours. With an increase in individual enoxaparin doses, less frequent dosing may be possible, thereby reducing owner inconvenience and expense. The three phases of this study investigated the appropriate dose (Phase one- 0.8mg/kg, SQ once; Phase two- 2mg/kg, SQ once; Phase three- 1.3 mg/kg, SQ q8h for 7 total doses) and dosing interval needed for maximum effectiveness of enoxaparin. A Sonoclot® analyzer and factor Xa activity were used to assess level of anticoagulation in six healthy dogs. Anticoagulation was inconsistent at the 0.8mg/kg dose, while the 2mg/kg dose showed a high level of anticoagulation, and the 1.3mg/kg dose provided more reliable anticoagulation than the other dosages and dosing intervals. Small sample size and the use of same-breed healthy dogs potentially affected the strength of the results.

URI

https://hdl.handle.net/11668/16960

Sponsorship

None

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