Advisor

Rashmir-Raven, Ann

Committee Member

Ryan, Peter

Committee Member

Elder, Steven

Date of Degree

1-1-2007

Document Type

Graduate Thesis - Open Access

Major

Veterinary Medical Science

Degree Name

Master of Science

College

College of Veterinary Medicine

Department

Department of Clinical Sciences

Abstract

The biomechanical and molecular characteristics of equine hyperelastosis cutis (HC) are not fully known. This study sought to better characterize HC by analysis of ultimate tensile strength, modulus of elasticity, toughness, and thickness of skin from 23 affected and unaffected horses. In addition total soluble collagen and glycosaminoglycan concentrations of skin were analyzed from 26 affected and unaffected horses. Affected horses' skin proved to be significantly weaker at five of seven sample locations (p<=0.05). The modulus of elasticity proved to be significantly different at three of seven sample locations and toughness at two of seven locations (p<=0.05). No significant difference was proven to exist between HC affected and unaffected horses for skin thickness or total soluble collagen and GAG concentrations. Collectively this data demonstrates that HC animals' reduced skin tensile strength is not due to a deficit of either collagen or GAG, but likely a result of altered collagen micro-architecture.

URI

https://hdl.handle.net/11668/17118

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