Wax, Benjamin, Jr.

Committee Member

Kavazis, Andreas N.

Committee Member

Vickers, John Bradley

Committee Member

Gilliland, Katherine S.

Date of Degree


Document Type

Graduate Thesis - Open Access


Glycine-arginine-alpha-ketoisocaproic acid (GAKIC) has been reported to enhance resistance performance during muscular strength and endurance protocols. PURPOSE: This study intended to investigate the potential ergogenic effects of GAKIC ingestion during repeated bouts of lower-body resistance exercise during a hypertrophy protocol. METHODS: Eleven resistance-trained males participated in a randomized, counterbalanced, double blind study. Participants were randomly assigned to placebo or GAKIC and performed five sets each of 67% of one-repetition maximum leg press, hack squat, and leg extension to failure. RESULTS: GAKIC supplementation significantly increased leg press repetitions, hack squat repetitions, and total load volume; however there was no significant difference in leg extension repetitions. Heart rate and blood lactate were significantly increased post-exercise compared to pre-exercise. Blood glucose was significantly decreased post-exercise compared to pre-exercise. CONCLUSIONS: We concluded that GAKIC increases total work performed during repeated bouts of lower-body resistance exercise.