Theses and Dissertations

Issuing Body

Mississippi State University


Wax, Benjamin, Jr.

Committee Member

Kavazis, Andreas N.

Committee Member

Vickers, John Bradley

Committee Member

Gilliland, Katherine S.

Date of Degree


Document Type

Graduate Thesis - Open Access


Sport Pedagogy

Degree Name

Master of Science (M.S.)


College of Education


Department of Kinesiology


Glycine-arginine-alpha-ketoisocaproic acid (GAKIC) has been reported to enhance resistance performance during muscular strength and endurance protocols. PURPOSE: This study intended to investigate the potential ergogenic effects of GAKIC ingestion during repeated bouts of lower-body resistance exercise during a hypertrophy protocol. METHODS: Eleven resistance-trained males participated in a randomized, counterbalanced, double blind study. Participants were randomly assigned to placebo or GAKIC and performed five sets each of 67% of one-repetition maximum leg press, hack squat, and leg extension to failure. RESULTS: GAKIC supplementation significantly increased leg press repetitions, hack squat repetitions, and total load volume; however there was no significant difference in leg extension repetitions. Heart rate and blood lactate were significantly increased post-exercise compared to pre-exercise. Blood glucose was significantly decreased post-exercise compared to pre-exercise. CONCLUSIONS: We concluded that GAKIC increases total work performed during repeated bouts of lower-body resistance exercise.