Theses and Dissertations

Issuing Body

Mississippi State University

Advisor

Elder, Steven H.

Committee Member

Liao, Jun

Committee Member

Cooley, Avery James

Committee Member

Prabhu, Rajkumar

Date of Degree

12-14-2013

Document Type

Graduate Thesis - Open Access

Major

Biomedical Engineering

Degree Name

Master of Science (M.S.)

College

James Worth Bagley College of Engineering

Department

Department of Agricultural and Biological Engineering

Abstract

Articular cartilage is an avascular, aneural tissue that covers the ends of diarthroidal joints. Once damaged by disease or injury, cartilage lacks the ability to self-repair. Generating tissue engineered cartilage is an exciting field that may provide a possible solution to this problem. The purpose of this study is to determine the efficacy of a through-thickness perfusion bioreactor to generate scaffoldree tissue engineered cartilage. The results of the study show that allowing long-term static culture to cell constructs before perfusion increases the efficacy of the bioreactor. Immediate perfusion of cell constructs in the bioreactor is shown to decrease the efficacy to produce scaffoldree constructs with desirable biomechanical and biochemical properties. The results of the study also show possible options in future works that could increase the efficacy of the bioreactor.

URI

https://hdl.handle.net/11668/18700

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