Theses and Dissertations

Issuing Body

Mississippi State University


Archer, Todd M.

Committee Member

Mackin, Andrew J.

Committee Member

Pharr, G. Todd

Committee Member

Cooley, Avery James

Date of Degree


Document Type

Graduate Thesis - Open Access


Veterinary Medical Science

Degree Name

Master of Science (M.S.)


College of Veterinary Medicine


Veterinary Medical Science Program


The role of histamine in chronic gastrointestinal diseases has been increasingly recognized in humans, but the role of histamine in the canine gastrointestinal tract has not been thoroughly investigated. The presence and distribution of all 4 histamine receptors (H1, H2, H3, and H4) in the stomach, duodenum, ileum, jejunum, and colon of healthy dogs were evaluated with a commonly employed immunohistochemistry technique using antibodies predicted to cross react with canine histamine receptors. All 4 histamine receptors were identified in the canine gastrointestinal tract, and differed in location and density within sections of the canine gastrointestinal tract. Antibody specificity was evaluated with Western blot. With the establishment of a method to study histamine receptors in the canine gastrointestinal tract, additional research to evaluate histamine receptors in dogs is warranted to further understand the pathophysiology and treatment of chronic canine enteropathies.