Williams, Lakiesha N.
Horstemeyer, Mark F.
Gwaltney, Steven R.
Stone, Tonya W.
Date of Degree
Graduate Thesis - Open Access
Master of Science
James Worth Bagley College of Engineering
Department of Agricultural and Biological Engineering
Mechanical injuries to the cell often lead to disruptions of the cell’s phospholipid bilayer membrane and potential detrimental effects including cell death. Understanding the mechanical states required to disrupt the phospholipid bilayer would result in better multiscale constitutive models and further knowledge of cell injury. The objectives of this research were to perform biaxial deformations of the phospholipid bilayer to quantify phospholipid bilayer disruption and to identify potential parameters that can be used in multiscale constitutive equations. We show that the von Mises stress, 26.6-61.1, increases linearly with the von Mises strain rate, 1.7e8-6.7e8, and that the strain at failure is dependent on the stress state with non- and equibiaxial being the most detrimental when failing at <.73 von Mises strain. Understanding the effects of nanoscale mechanical trauma to the cell provides a better understanding of cell injury and may provide insight regarding initiation and progression of cell damage.
Murphy, Michael Anthony, "POPC Phospholipid Bilayer Failure Under Biaxial Deformations Using Molecular Dynamics" (2014). Theses and Dissertations MSU. 3562.