Theses and Dissertations

Issuing Body

Mississippi State University


Butler, James Ryan

Committee Member

Syrcle, Jason

Committee Member

Brinkman, Erin

Committee Member

Baumgartner, Wes A.

Committee Member

Hanson, Larry

Other Advisors or Committee Members

Pruett, Stephen B.

Date of Degree


Document Type

Graduate Thesis - Open Access


Veterinary Medical Science

Degree Name

Master of Science


College of Veterinary Medicine


Department of Clinical Sciences


The ability of NSAIDs to delay bone healing has been long known, although the extent and exact mechanism remains elusive. The present study evaluates the effect of short duration NSAID on bone healing in dogs following experimental tibial osteotomy. Carprofen was administered twice daily for either 0, 2, or 8 weeks following surgery. Bone healing was evaluated radiographically using RUST scoring at 4 and 8 weeks postop. Postmortem, quantitative CT of for bone mineral density analysis, histologic cartilage:callus ratio of the fracture, and biomechanical testing were performed. Biomechanically, stiffness and maximum stress were higher in dogs that received no carprofen than those that received 8 weeks. Radiographic healing scores were the same for dogs which did not receive carprofen and those receiving a short course, but both were more healed than dogs which received 8 weeks of carprofen. There was no treatment effect on cartilage:callus ratio or bone mineral density.



American College of Veterinary Surgeons Foundation, Grant/Award Number: Surgeon in-Training Grant


Bone healing||Dogs||NSAID