Theses and Dissertations

Issuing Body

Mississippi State University


Ryan, Peter L.

Committee Member

Feugang, Jean M.N.

Committee Member

Filipov, Nickolay M.

Committee Member

Willard, Scott T.

Date of Degree


Document Type

Dissertation - Open Access


Agricultural Life Sciences (Animal Physiology)

Degree Name

Doctor of Philosophy


College of Agriculture and Life Sciences


Department of Animal and Dairy Sciences


Angiogenesis is a central process to both physiological and pathological aspects of living organisms. Understanding the angiogenic system via the key mediator, vascular endothelial growth factor (VEGF), has led to the development of biophotonic models capable of monitoring how this process is programmed. The whole animal model tested here is based on the involvement of angiogenesis in a wound healing environment. This model proved to be functional as a system monitor but lacked the precision to yield significant results between the biological compounds tested (estrogen, methoxychlor, and relaxin). The in vitro model is based on angiogenesis in a cancer environment. This model proved to be both a valid and functional way of monitoring the biological compounds tested (CoCl2, epinephrine, and norepinephrine).