Theses and Dissertations

Issuing Body

Mississippi State University

Advisor

Meyer, Florencia

Committee Member

Thornton, Justin

Committee Member

Rai, Aswathy

Date of Degree

4-30-2021

Original embargo terms

Visible to MSU only for 2 years

Document Type

Graduate Thesis - Open Access

Major

Biochemistry

Degree Name

Master of Science

Degree Name

Doctor of Philosophy (Ph.D)

College

College of Agriculture and Life Sciences

College

College of Agriculture and Life Sciences

Department

Department of Biochemistry, Molecular Biology, Entomology and Plant Pathology

Department

College of Agriculture and Life Sciences

Abstract

Bovine Respiratory Disease Complex is a multifactorial disease affecting cattle worldwide resulting in high mortality and morbidity rates in the cattle farming industry. This complex is caused by multiple viral and bacterial pathogens such as Bovine Herpesvirus-1, Bovine Respiratory Syncytial Virus, Mannheimia haemolytica, and Pasteurella multocida; two of the main contributors to the initiation of this disease are Bovine Herpesvirus-1 and the bacteria, Mannheimia haemolytica. Together, these microbes co-infect immunocompromised cattle during times of increased stress and induce a severe pneumonic response along with other health complications. Research has been primarily focused on these microorganisms individually or their effect on the host, however there is a need to study them together due to the increased mortality rate associated with co-infections. In this study, we used Bovine Herpesvirus-1, Mannheimia haemolytica, Pasteurella multocida, and Bovine Respiratory Syncytial Virus to co-infect bovine tissue cultures to determine how they affect each other.

Sponsorship

USDA NIFA

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