Theses and Dissertations

Issuing Body

Mississippi State University

Advisor

Lee, Alison

Committee Member

Seitz, Marc

Committee Member

Natalini, Claudio

Date of Degree

8-6-2021

Original embargo terms

Worldwide

Document Type

Graduate Thesis - Open Access

Major

Veterinary medicine

Degree Name

Master of Science

College

College of Veterinary Medicine

Department

Department of Clinical Sciences

Abstract

The main use of sildenafil in human medicine is to treat erectile dysfunction. In veterinary medicine, sildenafil is most frequently used to treat pulmonary hypertension. The effects of sildenafil on the portal vasculature in the dog have not been previously evaluated. The purpose of this study was to evaluate the effects sildenafil has on the portal vasculature. The cross-sectional area of the aorta, cross-sectional area of the portal vein, and portal vein velocity were acquired in thirteen dogs prior to administration, 45 minutes, 90 minutes, and 120 minutes after the oral administration of sildenafil for the treatment of pulmonary hypertension. No statistically significant difference was detected between all measured values at all time points. Although this study had a small sample size, sildenafil does not have a significant effect on the size of the portal vasculature. Further studies with a larger sample size will be required to further evaluate the effects.

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