Theses and Dissertations

Issuing Body

Mississippi State University


Conrad, Amanda

Committee Member

Tolar-Peterson, Terezie T.

Committee Member

Mathews, Rahel

Date of Degree


Document Type

Graduate Thesis - Campus Access Only



Degree Name

Master of Science (M.S.)


College of Agriculture and Life Sciences


Department of Food Science, Nutrition and Health Promotion


RED-S is a syndrome that stems from low energy availability (LEA) in athletes. It can impact numerous physiological and psychological functions, as well as negatively affect performance. Because RED-S is a relatively new syndrome, there are few studies showing the impact of RED-S on performance and physiological factors. The aim of this systematic review was to examine the consequences of induced LEA in relation to RED-S in male athletes. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, Five studies were deemed eligible based on inclusion and exclusion criteria. Studies measured risk of RED-S through body composition, bone mineral density, clinical biomarkers, and performance. Studies ranged in duration from 2- 8 weeks with a decrease in energy availability of 50% or 25%. Of the five studies investigated, data showed significant changes lactate metabolism and IGF-1,non-significant changes in body composition, and inconclusive changes in performance.