Mississippi State University
Date of Degree
Graduate Thesis - Open Access
Master of Science (M.S.)
College of Agriculture and Life Sciences
Department of Poultry Science
Avian pathogenic Escherichia coli (APEC) is a bacterium that is responsible for colibacillosis in birds. However, information about broiler breeder APEC isolates is limited, but the data is critical due to the transfer of this bacteria down the production pyramid to progenies resulting in high mortality. Therefore, we evaluated the phenotypic virulence characteristics of 28 isolates using embryo lethality and day-old chick challenge assays. Also, the in vitro adhesion and invasion potential of selected nine isolates were identified. Results showed more than 1/3rd of the isolates were highly virulent and the virulence increased as the number of virulence-associated genes increased. High adhesion and invasion rates were observed among the isolates. Overall, the study helped us to evaluate the virulence characteristics of APEC from broiler breeders. However, future studies based on whole genome approach would help to identify the specific targets which can be used to develop effective interventions.
Joseph, Jiddu, "Evaluation of the virulence potential of avian pathogenic Escherichia coli isolated from broiler breeders with colibacillosis in Mississippi" (2023). Theses and Dissertations. 5976.
Animal Diseases Commons, Animal Experimentation and Research Commons, Bacteriology Commons, Pathogenic Microbiology Commons, Poultry or Avian Science Commons, Veterinary Microbiology and Immunobiology Commons