Degree

Bachelor of Science (B.S.)

Major(s)

Microbiology

Document Type

Immediate Open Access

Abstract

Occidiofungin is a natural antifungal compound produced by Burkholderia contaminans MS14. Prior work has been shown occidiofungin to be effective against Candida albicans in its nonpathogenic yeast form. However, C. albicans is an opportunistic pathogen that requires a morphogenic switch to a filamentous form to cause disease. As previous work focusing on the non-pathogenic form has shown distinct biochemical and morphological changes with occidiofungin exposure, I hypothesis that the filamentous form of this fungi will also undergo identifiable changes that can be characterized. To this end, cells induced to undergo morphological switching in the presence of occidiofungin were analyzed by standard microbiological methods. Data showed that a lethal dose of the antifungal prevented hyphae formation while a sublethal dose slowed filament growth without obvious alterations in cell wall organization. These data adds to our understanding of occidiofungin’s potential as an antifungal compound to combat the pathogenic form of Candida albicans.

DOI

https://doi.org/10.54718/DHTO8074

Date Defended

5-1-2019

Thesis Director

Gordon, Donna M.

Second Committee Member

Thornton, Justin A.

Third Committee Member

Oppenheimer, Seth

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