Theses and Dissertations
Issuing Body
Mississippi State University
Advisor
Emerson, Joseph P.
Committee Member
Sygula, Andrzej
Committee Member
Mlsna, Todd
Committee Member
Scott, Colleen N.
Committee Member
Oliver, Allen G.
Date of Degree
12-14-2018
Document Type
Dissertation - Open Access
Major
Chemistry
Degree Name
Doctor of Philosophy
College
College of Arts and Sciences
Department
Department of Chemistry
Abstract
Aziridines and cyclopropanes are valued as important building blocks for the synthesis of a wide range of organic compounds, including biologically active compounds and pharmaceuticals. The development for more efficient and cost-effective catalysts for the atom transfer reaction with olefins is a continuing area of research in both organic and inorganic chemistry. Transition metal complexes, which catalyze reactions of olefins with nitrenes and carbenes, are well-developed efficient, approaches to the direct synthesis of aziridines and cyclopropanes, but traditionally rely on expensive synthetic methods. As part of our efforts in the catalytic formation of C—C and C—N bonds, herein we show the development of a new and efficient copper(II) catalysts that exhibits high reactivity forming cyclopropanes and aziridines from a range of olefins. These catalytic systems have also shown a propensity to conduct these atom-transfer reactions in aqueous solutions, affording the opportunity to use bio-macromolecules, like DNA, to induce enantioselectivity.
URI
https://hdl.handle.net/11668/18558
Recommended Citation
Valle, Henry U., "Copper(II) Complexes for Olefin Aziridination and Cyclopropanation: Towards Asymmetric N- and C- Transfer Catalyst" (2018). Theses and Dissertations. 1192.
https://scholarsjunction.msstate.edu/td/1192