Theses and Dissertations
Issuing Body
Mississippi State University
Advisor
Priddy, Lauren
Committee Member
Prabhu, Raj
Committee Member
Moore, Talisha
Committee Member
Yadollahi, Aref
Date of Degree
5-1-2020
Original embargo terms
Worldwide
Document Type
Graduate Thesis - Open Access
Major
Biomedical Engineering
Degree Name
Master of Science
College
James Worth Bagley College of Engineering
Department
Department of Agricultural and Biological Engineering
Abstract
In recent years, repetitive traumatic brain injuries have been linked to the progressive neurodegenerative disorder termed chronic traumatic encephalopathy. However, the mechanical characteristics of brain tissue exposed to repetitive loading still lack understanding. This research evaluated the response of porcine brain tissue undergoing cyclic, compressive loading in reference to three impact parameters: cycle number (N25, N50, N100, N150, and N200), strain level (15, 30, and 40%), and strain rate (0.00625, 0.025, 0.10, and 1.0/s). Following mechanical testing, tissue samples were processed for hematoxylin and eosin (H&E) staining. Stress values, hysteresis energy, and decreases in hysteresis energy for all parameters were compared. The data suggest that microstructural brain tissue damage is highly dependent on strain level and cycle number, whereas strain rate did not appear to cause permanent damage in the quasi-static range applied. The onset of permanent microstructural tissue damage may relate to movement of fluid molecules within the tissue.
URI
https://hdl.handle.net/11668/16699
Recommended Citation
Sebastian, Kali, "Defining the mechanical characteristics of porcine brain tissue subject to cyclic, compressive loading" (2020). Theses and Dissertations. 1267.
https://scholarsjunction.msstate.edu/td/1267