Theses and Dissertations
Issuing Body
Mississippi State University
Advisor
Eells, Jeffrey B.
Committee Member
Varela-Stokes, Andrea S.
Committee Member
Carr, Russell
Date of Degree
5-7-2016
Document Type
Graduate Thesis - Open Access
Major
Infectious Disease
Degree Name
Master of Science (M.S.)
College
College of Veterinary Medicine
Department
Veterinary Medical Science Program
Abstract
Toxoplasma gondii infection is common in humans and is a significant risk factor for developing the disease schizophrenia. Genetic risk factors are likely required for the disease of schizophrenia to develop. Nurr1 – heterozygous (+/-) mice and wild-type (+/+) mice were evaluated using immune activation of astrocytes within the prefrontal cortex, dopamine levels within the striatum, and measuring the acoustic startle response reaction time by using prepulse inhibition (PPI). T. gondii infected heterozygous (+/-) mice exhibited increased GFAP expression within the prefrontal cortex. Dopamine levels within the striatum were measured and T. gondii infected wild-type (+/+) mice exhibited increased dopamine levels. The acoustic startle response reaction time was measured using PPI and T. gondii infected mice exhibited slower reaction times when compared to controls. These data demonstrate that the Nurr1 (+/-) genotype predisposes mice to T. gondii-induced alterations in behaviors that involve dopamine neurotransmission and are associated with symptoms of schizophrenia.
URI
https://hdl.handle.net/11668/16636
Recommended Citation
Bramlett, Derek Lee, "Effect of Toxoplasma gondii on Altering Dopamine Levels and Neuroinflammation Contributing to an Increased Risk of Developing Schizophrenia" (2016). Theses and Dissertations. 1692.
https://scholarsjunction.msstate.edu/td/1692