Theses and Dissertations

Issuing Body

Mississippi State University

Advisor

McLaughlin, Ronald

Committee Member

Mackin, Andrew

Committee Member

Langston, Cory

Committee Member

Lunsford, Kari

Committee Member

Pinchuk, Lesya

Date of Degree

8-7-2010

Document Type

Graduate Thesis - Open Access

Major

Veterinary Medical Science

Degree Name

Master of Science (M.S.)

College

College of Veterinary Medicine

Department

Veterinary Medical Science Program

Abstract

Little research has been published evaluating the effect of non-steroidal antiinflammatory drugs (NSAIDs) on platelet function in dogs. The effects of aspirin and cyclooxygenase-2 (COX-2) selective NSAIDS on platelet function were evaluated. Eight dogs received aspirin 10 mg/kg PO every 12 hours for 10 days, and then were randomly assigned to 4 groups, with each group receiving one of the following PO for 7 days in a crossover study design: carprofen 2.2 mg/kg every 12 hours, carprofen 4.4 mg/kg every 24 hours, meloxicam 0.2 mg/kg every 24 hours first day then 0.1 mg/kg every 24 hours for 6 days, or deracoxib 2 mg/kg every 24 hours. PFA-100® platelet function analysis with collagen/ADP and collagen/EPI cartridges, viscoelastometry, and urine 11-dehydrothromboxane B2 were evaluated. All drugs significantly prolonged PFA-100® closure times with the collagen/EPI cartridge, but not with collagen/ADP. Urine 11-dehydrothromboxane B2 levels were significantly lower after aspirin but no other drugs.

URI

https://hdl.handle.net/11668/15478

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