Theses and Dissertations

Issuing Body

Mississippi State University

Advisor

Wang, Chinling.

Committee Member

Ross, Matthew K.

Committee Member

Pharr, Todd G.

Date of Degree

5-4-2018

Document Type

Graduate Thesis - Open Access

Major

Veterinary Medical Research

Degree Name

Master of Science (M.S.)

College

College of Veterinary Medicine

Department

Veterinary Medical Science Program

Abstract

Chickens in the poultry industry are reared under intensive conditions where they are often exposed to opportunistic pathogens. Escherichia coli strain O78 is responsible for about half of the cases of avian colisepticemia. Potential therapeutic treatments have been proposed to inhibit the hydrolases that controls the endogenous levels of the endocannabinoid, 2-arachidonoylglycerol (2-AG). 2-AG is the full agonist at the CB2 receptors of the endocannabinoid system expressed among leukocytes and it plays a role in mediating the activation of phagocytic macrophages. It is speculated that elevating 2- AG levels could increase macrophage cytokines and promote the recruitment of immune cells at the infected tissues. The purpose of this study was to investigate the immunomodulating effect of the 2-AG hydrolase inhibitor, JZL184 in chickens. The treatments could potentially up-regulate the innate immune responses in chickens during an E. coli infection by conveying a message from the endocannabinoid system to the immune system.

URI

https://hdl.handle.net/11668/16716

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