Theses and Dissertations
Issuing Body
Mississippi State University
Advisor
Warnock, James
Committee Member
Liao, Jun
Committee Member
Cooper, Robert
Committee Member
Elder, Steven
Date of Degree
12-13-2008
Document Type
Graduate Thesis - Open Access
Major
Biomedical Engineering
Degree Name
Master of Science (M.S.)
College
James Worth Bagley College of Engineering
Department
Department of Agricultural and Biological Engineering
Abstract
Children born with congenital heart valve defects require open-heart surgery to implant an artificial replacement valve. These valves are unable to grow with the developing child and need replacing every 5 years. Tissue engineered heart valves, capable of growing with the patient, would alleviate the need for repeat surgery. I hypothesize chitosan and collagen possess advantageous qualities as scaffolding for a tissue engineered heart valve. This study evaluated chitosan and collagen hydrogels as potential scaffold materials. Chitosan scaffolds had suitable pore size/distribution and scaffold strength; however, they were unable to sustain cell attachment or viability. Collagen gels were assessed for compaction, mechanical properties and expression of matrix metalloproteases in the presence or absence of biochemical and mechanical stimuli. Pressure increased the remodeling potential. This was augmented further in the presence of TGF-β. In conclusion, both materials have potential as scaffolding substrate in a tissue engineered heart valve.
URI
https://hdl.handle.net/11668/17236
Recommended Citation
Waller, Steven Christopher, "Evaluation Of Chitosan And Collagen As Scaffolding For A Tissue Engineered Aortic Heart Valve" (2008). Theses and Dissertations. 2005.
https://scholarsjunction.msstate.edu/td/2005