Theses and Dissertations

Issuing Body

Mississippi State University

Advisor

McLaughlin, Ron

Committee Member

Langston, Cory

Committee Member

Cooper, C. Robert

Date of Degree

8-7-2010

Document Type

Graduate Thesis - Open Access

Major

Veterinary Medical Science

Degree Name

Master of Science (M.S.)

College

College of Veterinary Medicine

Department

Veterinary Medical Science Program

Abstract

The objective of this study was to determine elution properties of meropenem and compare the elutions of meropenem impregnated PMMA beads without sterilization (PMMA-Cont) to those sterilized with steam (PMMA-Auto) and ethylene oxide gas (PMMA-EO). Four groups of beads were produced: one group without antibiotic and three groups of meropenem impregnated beads: PMMA-Cont, PMMA-Auto, and PMMA-EO. Antibiotic concentrations in eluent samples were determined using a microbiological assay at different time intervals. The microbiological assay resulted in no zone of inhibition at all time periods for the PMMA-Auto samples and the samples of PMMA without antimicrobial. The meropenem concentration on the eluent remained above 4 mcg/ml for 15 days in the PMMA-Cont group and until day 18 for PMMA-EO group. The meropenem incorporated in the PMMA beads elutes effectively and gradually decreases after the 24 hour peak. Ethylene oxide does not adversely affect meropenem’s elution.

URI

https://hdl.handle.net/11668/15533

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