Theses and Dissertations

Issuing Body

Mississippi State University

Advisor

Lemley, Caleb O.

Committee Member

Larson, Jamie

Committee Member

Rude, Brian J.

Date of Degree

12-13-2014

Document Type

Graduate Thesis - Open Access

Major

Animal Science

Degree Name

Master of Science (M.S.)

College

College of Agriculture and Life Sciences

Department

Department of Animal and Dairy Sciences

Abstract

The objective of this study was to examine hepatic steroid inactivation and luteal function throughout bovine gestation. In pregnant beef cows, cytochrome P450 3A activity decreased from mid- to late-gestation, while progesterone concentrations tended to increase from mid- to late-gestation. Uridine diphosphate-glucuronosyltransferase activity per kg of body weight was increased in pregnant vs non-pregnant dairy cows. Total corpus luteum (CL) blood perfusion tended to be increased in pregnant vs non-pregnant dairy cows. Hepatic portal blood flow per kg of body weight was increased in pregnant vs non-pregnant dairy cows. Hepatic steroid inactivating enzyme activity, CL blood perfusion, and portal blood flow did not differ between pregnant and non-pregnant beef cows. There was no difference in progesterone concentrations in pregnant vs non-pregnant dairy or beef cows. The current study highlights the relevance of further investigation into steroid secretion and inactivation and their impact on the maintenance of pregnancy in cattle.

URI

https://hdl.handle.net/11668/18892

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