Theses and Dissertations

Issuing Body

Mississippi State University

Advisor

Kaplan, Barbara L.F.

Committee Member

Ross, Matthew

Committee Member

Eells, Jeffrey

Committee Member

Pruett, Stephen

Committee Member

Morgan, Timothy

Date of Degree

5-1-2020

Document Type

Dissertation - Open Access

Major

Veterinary Medical Research

Degree Name

Doctor of Philosophy

College

College of Veterinary Medicine

Department

Veterinary Medical Science Program

Abstract

One of the major focuses for our lab involves examining the immunosuppressive properties of various agents and receptors in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). This dissertation encompasses an investigation of cannabidiol in the EAE model, the endocannabinoid CB1 receptor in the EAE model, staphylococcal superantigens (SAgs) as immunosuppressive agents, and various aspects of the EAE model. The first chapter covers the existing literature pertinent to these studies, the second and third chapters cover the material, methods, and results from the studies, and the fourth chapter is a discussion of how those results fit into the existing body of literature. A fifth chapter has also been included which covers two additional studies designed to develop alternative EAE models for our lab; however, both studies turned out differently than expected. One of the most interesting developments from this final chapter was the discovery of an age dependent difference in the memory T cell response of older mice, which allows for more robust disease to be induced when cells from 6 month old mice are used in the passive EAE (P-EAE) model as opposed to mice 10 weeks of age.

URI

https://hdl.handle.net/11668/16677

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