Innate Immunity and Inflammation in Sepsis in a Mouse Model for Binge Drinking

Author

Basit Latief Jan

Issuing Body

Mississippi State University

Advisor

Pruett, Stephen B.

Committee Member

Pharr, G. Todd

Committee Member

Nanduri, Bindu

Date of Degree

12-10-2010

Document Type

Graduate Thesis - Open Access

Major

Veterinary Medical Science

Degree Name

Master of Science

College

College of Veterinary Medicine

Department

Department of Basic Sciences

Abstract

Alcohol consumption is a significant riskactor for mortality in patients with sepsis. This study was carried to investigate the mechanisms by which acute ethanol exposure alters the course of sepsis and the effect of TLR4 signaling. Ethanol administration decreases resistance to E. coli and causes decrease in the ability to clear bacteria both from the peritoneal-cavity as well as the spleen. At early time-points, ethanol also suppresses the production of pro-inflammatory cytokines. TLR4 is dispensable for survival in E. coli sepsis but it also contributes to lethality in wild-type mice. Although TLRs have been implicated as an important element of host defense against infections, evidence indicates that these receptors may also play a crucial role in the pathophysiology of sepsis.

URI

https://hdl.handle.net/11668/20775

Comments

TLR4||Ethanol

Recommended Citation

Jan, Basit Latief, "Innate Immunity and Inflammation in Sepsis in a Mouse Model for Binge Drinking" (2010). Theses and Dissertations. 2741.
https://scholarsjunction.msstate.edu/td/2741