Theses and Dissertations
Issuing Body
Mississippi State University
Advisor
Elder, Steven H.
Committee Member
Simpson, Chartrisa LaShan
Committee Member
Liao, Jun
Committee Member
Butler, James Ryan
Date of Degree
12-9-2016
Document Type
Graduate Thesis - Open Access
Major
Biomedical Engineering
Degree Name
Master of Science
College
James Worth Bagley College of Engineering
Department
Department of Agricultural and Biological Engineering
Abstract
With Athletes and individuals developing osteoarthritis and chondral defects at younger ages, long term treatments are in high demand. Total knee replacements only last for 10-15 years, so younger individuals would need to have multiple knee replacements within their lifetime. Allograft transplantation has shown to last long term and have high success rates, but the lack of donors and the possibility of damaging other areas of the knee to obtain tissue grafts has become a large concern. Xenografts derived from porcine cartilage is cost effective and the supply is abundant. Two antigen removal processes were examined: a short term antigen removal process to maintain the mechanical stability of the tissue, and a long antigen removal process to minimize the risk of triggering an immune response. The antigen removal processes were compared, and the future precautions were determined to enhance the probability of creating a viable osteochondral xenograft preparation technique.
URI
https://hdl.handle.net/11668/20358
Recommended Citation
Kindred, Bradley Jeffery, "Investigating the Antigen Removal Process of Porcine Cartilage in Preparation of Creating an Osteochondral Xenograft" (2016). Theses and Dissertations. 2812.
https://scholarsjunction.msstate.edu/td/2812
Comments
biomechanics||osteochondral||antigen removal||xenograft||cartilage