Theses and Dissertations

Issuing Body

Mississippi State University


Donaldson, Janet R.

Committee Member

Carroll, Jeffery A.

Committee Member

Stewart, James A., Jr.

Committee Member

Thornton, Justin A.

Date of Degree


Document Type

Graduate Thesis - Open Access

Degree Name

Master of Science


College of Arts and Sciences


Department of Biological Sciences


The environment of the gastrointestinal (GI) tract is an extremely complex system made up of not only host cells, but also many beneficial microbes. Disruption of this environment can often lead to disorders and health issues. To help balance this system, probiotics have often been administered to both humans and animals, such as livestock. This study aimed to determine what beneficial effects a novel strain of Enterobacter cloacae, strain JD6301, could offer to a host in the presence of an enteric infection with E. coli O157:H7. Upon administration of JD6301, supplemented animals had overall less E. coli present in the colon and caecum. Moreover, these animals shed more E. coli than control groups. Supplemented animals also had increased concentrations of serum triglycerides one day prior to challenge. Together, these data suggest that Enterobacter cloacae JD6301 could perform as a novel probiotic providing energy and protection to the host.



Escherichia coli||probiotic||Enterobacter cloacae