Novel methods for detecting glycan receptors for influenza A virus and exploration of the function of the sialyltransferases on influenza viral infection

Author

Kaijun Jiang

Issuing Body

Mississippi State University

Advisor

Wan, Xiufeng (Henry)

Committee Member

Pharr, G. Todd

Committee Member

Hanson, Larry

Committee Member

Hoblet, Kent H.

Date of Degree

8-9-2019

Original embargo terms

Worldwide

Document Type

Graduate Thesis - Open Access

Major

Veterinary Medical Science

Degree Name

Master of Science

College

College of Veterinary Medicine

Department

Department of Basic Sciences

Abstract

Sialic acids (Sias) are receptors for influenza A viruses (IAVs). The influence of individual sialyltransferases on the Sias expressed is not understood. Also, sensitive methods to distinguish Sias on the cells are lacking. Our goals were to establish a method to detect Sias on the cell and to evaluate the importance of CMP-sialic acid transporter (SLC35A1) and ST6 beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) for IAV infection. Aproximity ligation assay was established to detect and quantify Sias.

URI

https://hdl.handle.net/11668/14591

Comments

Influenza virus||silica acid receptor||CRISPR||PLA

Recommended Citation

Jiang, Kaijun, "Novel methods for detecting glycan receptors for influenza A virus and exploration of the function of the sialyltransferases on influenza viral infection" (2019). Theses and Dissertations. 3315.
https://scholarsjunction.msstate.edu/td/3315