Theses and Dissertations
Issuing Body
Mississippi State University
Advisor
Chambers, Janice
Committee Member
Chambers, Howard
Committee Member
Carr, Russell
Date of Degree
5-9-2015
Original embargo terms
MSU Only Indefinitely
Document Type
Graduate Thesis - Campus Access Only
Major
Veterinary Medical Science
Degree Name
Master of Science
College
College of Veterinary Medicine
Department
Veterinary Medical Science Program
Abstract
The aim of this study was to determine the ability of twenty novel substituted phenoxyalkyl pyridinium oximes to reactivate phosphylated acetylcholinesterase (AChE) in peripheral rat tissues, in vitro, inhibited by organophosphate anticholinesterase nerve agent surrogates. A sarin surrogate, phthalimidyl isopropyl methylphosphonate (PIMP), and a VX surrogate, 4-nitrophenyl ethyl methylphosphonate (NEMP), were used to inhibit AChE in skeletal muscle and serum samples. Reactivation of the widely used oxime 2-PAM was tested for comparison with the novel oximes. The novel oximes displayed a range of 23-102% reactivation of AChE in vitro across both tissue types. Most of the novel oximes tested in the present study demonstrated a higher percent reactivation of AChE, than 2-PAM. Therefore, these novel oximes have the potential to be effective antidotes used during the treatment of OP toxicity.
URI
https://hdl.handle.net/11668/17995
Recommended Citation
Bennett, Joshua Peay, "Reactivation of Acetylcholinesterase Inhibited by Organophosphates in Peripheral Rat Tissues" (2015). Theses and Dissertations. 3725.
https://scholarsjunction.msstate.edu/td/3725