Theses and Dissertations
Issuing Body
Mississippi State University
Advisor
Swiderski, Cyprianna E.
Committee Member
Bowser, Jacquelyn E.
Committee Member
Brashier, Michael
Date of Degree
5-3-2019
Original embargo terms
Worldwide
Document Type
Graduate Thesis - Open Access
Major
Veterinary Clinical Sciences
Degree Name
Master of Science
College
College of Veterinary Medicine
Department
Veterinary Medical Science Program
Abstract
Pasture-associated severe equine asthma (EPA) is a progressive condition affecting horses in the southeastern United States. Pulmonary function testing with methacholine challenge (MC) provides a definitive diagnosis by eliciting airway hyper-responsiveness. Most horses require extensive conditioning to accept the instrumentation. Our hypothesis was that MC protocols designed to elicit airway hyper-responsiveness would yield equivalent results in the presence and absence of sedation. Sedated and unsedated MCs were performed on 8 EPA-affected horses, with each horse acting as its own control. Acepromazine was superior to xylazine/butorphanol, resulting in sedation and data collection. Based on American Thoracic Society guidelines, an acceptable ability to detect differences in lung resistance is less than a twofold difference in the provocative concentration of methacholine that elicited a 40% increase in lung resistance (PC40RL). Significant differences in PC40RL were not detected. Validation of a sedation protocol for use in MC will expand the application of this diagnostic.
URI
https://hdl.handle.net/11668/21239
Recommended Citation
Lack, Amy Catherine, "Sedated Versus Non-Sedated Methacholine Challenge for the Diagnosis of Airway Hyper-Responsiveness in Horses" (2019). Theses and Dissertations. 3881.
https://scholarsjunction.msstate.edu/td/3881
Comments
equine||airway disease||pulmonary function testing||methacholine challenge