Theses and Dissertations
Issuing Body
Mississippi State University
Advisor
Walters, Keisha
Committee Member
Hill, Priscilla
Committee Member
Elmore,Bill
Date of Degree
8-9-2008
Original embargo terms
MSU Only Indefinitely
Document Type
Graduate Thesis - Campus Access Only
Major
Chemical Engineering
Degree Name
Master of Science
College
James Worth Bagley College of Engineering
Department
Dave C. Swalm School of Chemical Engineering
Abstract
Selective ester bond cleavage using lithium and zinc halides was attempted in a select group of phospholipids, namely phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS). Several reaction parameters including catalyst (lithium chloride, lithium bromide, lithium iodide, zinc chloride, zinc bromide and zinc iodide), reaction temperature (21, 30, 50 and 60 oC), and reaction time (2 and 4 hours) were varied and the effects on cleavage studied. Reacted phospholipid samples were characterized by attenuated total reflectance (ATR) and transmission FTIR spectroscopy. The FTIR spectra of pure (unreacted) and reacted PC, PE and PE were analyzed qualitatively and quantitatively (Peak Height Ratio). The appearance of asymmetric carboxylate anion stretch (1577 cm-1) and symmetric phosphonyl dianion stretch (1006 cm-1) in the reacted phospholipid spectra reveals cleavage of ester bonds in carbonyl and phosphonyl. Reaction temperature and time did not significantly influence the cleavage results over the temperature and time range tested.
URI
https://hdl.handle.net/11668/16333
Recommended Citation
Mohan, Vijitha, "Selective ester cleavage in phospholipids" (2008). Theses and Dissertations. 3898.
https://scholarsjunction.msstate.edu/td/3898
Comments
cleavage of ester bonds